CD Skripsi

Isolasi Dan Seleksi Bakteri Penghasil Dekstran Dari Nira Kelapa: Upaya Mencari Penghantar Obat Berbasis Nano

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ABSTRACT
Dextran is a homopolysaccharide α-glucan from glucose. Dextran has a diverse structure and properties so that it is widely applied in various industrial fields such as in the pharmaceutical field which is used as a drug carrier. Drugs have toxicity that is difficult to predict so they require drug delivery to more easily reach target cells and reduce drug side effects. Dextran has a small size with properties that are easily degraded by enzymes so that it has the potential to be a drug carrier. Dextran as a drug carrier can be isolated from bacterial isolates on sucrose-enriched medium. This research aims to isolate and select dextran-producing bacteria and their potential as nano-based drug carriers. Bacterial isolation from coconut sap samples taken from 4 different locations was isolated by spread plate technique using dextran-selective medium. Dextran-producing bacteria are characterized by mucoid and ropy colonies that furthermore purified to obtain a single isolate. Based on the isolation of bacteria from coconut sap, 6 isolates of bacteria capable of producing dextran were obtained. Dextran production is carried out by fermentation on a medium enriched with 15% sucrose and gets the highest production of 18 g/L produced by NPL 1.3 isolate. Next, the viscosity of dextran is carried out with an Ostwald viscometer. The highest viscosity of dextran obtained was 1,27 cP at a concentration of 2,5% by dextran from NPL 1.2 isolate. The viscosity of dextran that can be used as a nano-based drug delivery is 37 cP to 396 cP. The viscosity of 6 dextrans obtained is still relatively low so it needs a higher concentration of dextran so that it can be used as a nano-based drug carrier.
Key findings: Dextran-producing bacteria, dextran, coconut sap, isolation, drug carrier.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1903155735

Penerbit

Pekanbaru : Universitas Riau - FMIPA - Biologi., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1903155735

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

BIOLOGI

Info Detail Spesifik

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Pernyataan Tanggungjawab

tethi

Versi lain/terkait

Lampiran Berkas

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