CD Tesis

Polimorfisme Gen Reseptor Vitamin D (RVD) Apai Pada Dewasa Muda Dengan Obesitas Sentral

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ABSTRACT

The activity of vitamin D is controlled by the Vitamin D Receptor (VDR), which is located in many body cells. Vitamin D is often associated with obesity. Obesity based on fat distribution is known as central obesity which can be influenced by many factors, such as environmental and genetic factors. The genetic factor suspected to be a risk factor for obesity is the polymorphism of the VDR gene. The VDR gene has several polymorphisms, namely BsmI, ApaI, TaqI, and FokI. The purpose of this research was to determine the differences in ApaI polymorphism of the VDR gene between central obesity and non-central obesity in young adults. The design of this research was analytical with cross-sectional approach. Identification of ApaI polymorphism was conducted using the Amplification Refractory Mutation System Polymerase Chain Reaction (ARMS-PCR). The research subjects totaled 51, who were students from faculty of medicine and faculty of nursing Riau University, consisting of 32 female (62.7%) and 19 male (37.3%). The average age of research subjects was 19.33 ± 1.012 years. There were 36 subjects (70.6%) who experienced central obesity. The highest genotype frequency in central obesity group was Aa at 16 (44.4%), and also in the non-central obesity group at 8 (53.3%). The highest allele frequency in central obesity group was a allele at 46 (63.9%), and also in the non- central obesity group it was 18 (60%). There was no significant difference in the frequency of the ApaI genotype and allele between central obesity and non-central obesity groups (P value >0,05).

Keywords: Central obesity, Polymorphism, VDR, ApaI

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2008111237

Penerbit

Pekanbaru : Universitas Riau - FK – Pendidikan Dokter., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2008111237

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN DOKTER

Info Detail Spesifik

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Pernyataan Tanggungjawab

Jaka

Versi lain/terkait

Lampiran Berkas

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