CD Skripsi
Efek Ekstrak Inulin Umbi Dahlia Terhadap Perlemakan Hati Pada Tikus Diabetes Melitus Tipe 2
ABSTRACT
Fatty liver is highly prevalent in type 2 diabetes mellitus (T2DM), where the mechanism is related to obesity and insulin resistance in T2DM. Fatty liver is characterized by the accumulation of lipids in the liver (steatosis) in response to excessive triglyceride synthesis in hepatocytes and may be related to intestinal microbiota disturbances. The prebiotic inulin is a naturally occurring polysaccharide with high dietary fiber content. The aims of this study was to determine the effects of administering inulin from dahlia tubers on fatty liver in T2DM rats. The research design is a laboratory experiment with a post-test-only control group design conducted from June to November 2023. The study used the male Rattus norvegicus Wistar strain divided into five groups: a control group, a T2DM induced group, T2DM groups given inulin extract at doses of 0,5 mg/gBW, 1,0 mg/gBW, and 1,5 mg/gBW. The results showed that the highest percentage of fatty liver in the T2DM group and the lowest in the control group. Compared to the T2DM group, there was a decrease in the percentage of fatty liver in the T2DM groups given inulin at all doses (p
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