CD Skripsi

Analisis Bioinformatika Proses Biologis Sel Epitel Serviks Pada Pasien Karsinoma Serviks Yang Terinfeksi HPV16 & HPV18

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ABSTRACT
Cervical carcinoma is a malignancy of cervical epithelial cells with a high incidence and mortality rate. The majority of cases of cervical carcinoma are caused by HPV16 and HPV18 infections. Based on the prognosis, HPV16 has better prognosis than HPV18. The difference in prognosis indicates differences in biological processes due to differences in gene expression levels between the two types. Three gene expression profiles were analyzed (GSE9750, GSE151666, and GSE6791) from the GEO database using GEO2R and Volcano plot. The analysis was performed to identify differences in gene expression. Differentially expressed genes were analyzed using over-representation analysis (ORA) based on biological processes to obtain a group of genes based on biological processes. Three biological processes was found with significant values, divalent inorganic cation transport being the most significant biological process. The genes that contribute to this biological process are ATP2B3, NTSR1, CAMK2B, EPO, TRPM5, and CACNG4. The expressions of those six genes are decreased in HPV16 compared to HPV18. This study suggests the role of calcium homeostasis in carcinogenesis due to HPV which has the potential to become a target in therapy development for cervical carcinoma patients.
Keyword : Bioinformatics analysis, human papillomavirus, cervical carcinoma, biological process

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2008113781

Penerbit

Pekanbaru : Universitas Riau - FK – Pendidikan Dokter., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2008113781

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN DOKTER

Info Detail Spesifik

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Pernyataan Tanggungjawab

Jaka

Versi lain/terkait

Lampiran Berkas

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