CD Skripsi

Fanalisis Ekspresi Gen Androgen Receptor (Ar) Dan Karakteristik Klinis Pasien Kanker Ginjal Tipe Clear Cell Carcinoma

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Clear Cell Renal Cell Carcinoma (ccRCC) is a malignancy of the renal cortex characterized by clear cytoplasm and dense alveolar with branched vascularization. Previous studies have confirmed that Androgen Receptor (AR) is involved in the regulation of Renal Cell Carcinoma (RCC) initiation and progression. AR is a gene that mediates the mechanism of action of the androgen hormone and acts as a ligand-dependent transcription factor that controls the expression of spesific genes. The aim of this study was to analyze AR gene expression with clinical characteristics of ccRCC patients. This study is an observational analytic study with cross-sectional research design and total sampling method. From the results of this study, it was found that AR gene expression was lower in normal kidney tissue than ccRCC tissue, while AR protein expression was found to be higher in normal kidney tissue than ccRCC tissue. In addition, AR gene expression was also found to be higher in the early stage, grade 1, and white race. The conclusion of this study is that there is a significant difference between AR gene and protein expression in normal kidney tissue compared to ccRCC tissue. Significant differences were also found between AR gene expression in stage, grade, and race groups of ccRCC patients. From this research, it can be developed by discussing the prognosis in ccRCC with AR gene expression, this can be used as information for planning strategies for therapy for this subtype of kidney cancer.

Keywords: Androgen Receptor, Clear Cell Renal Cell Carcinoma, Clinical Characteristics 

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2008113723

Penerbit

Pekanbaru : Universitas Riau - FK – Pendidikan Dokter., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2008113723

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN DOKTER

Info Detail Spesifik

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Pernyataan Tanggungjawab

Jaka

Versi lain/terkait

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