Image of Sintesis, Uji Potensi Antioksidan Dan Antikanker Analog Flavonol Turunan 2’-Hidroksi Kalkon
Penanda Bagikan

CD Tesis

Sintesis, Uji Potensi Antioksidan Dan Antikanker Analog Flavonol Turunan 2’-Hidroksi Kalkon

Seven Flavonol derived of 2'-hydroxycalone are 2- (2-methoxyphenyl) -3-hydroxy-4H-kromen-4-on (F4), 2- (3-methoxyphenyl) -3-hydroxy-4H-kromen-4-7 on (F5), 2- (4-methoxyphenyl) -3-hydroxy-4H-kromen-4-on (F6), 2- (2,3-dimetoksifenil) -3-hydroxy-4H-kromen-4-on (F7), 2- (2,5-dimethoxyphenyl) -3-hydroxy-4H-kromen-4-on (F8), 2- (3,4-dimetoksifenil) -3-hydroxy-4H-kromen-4-on (F9) and 2- (3,4,5-dimethoxyphenyl) -3-hydroxy-4H-kromen-4-on (F10) have been synthesized under basic condition (KOH). The resulting yield varies greatly, which is equal to 57.4-83.03%
The results of the characterization using UV-Vis spectroscopy, FTIR, 1H NMR, and HRMS showed that all compounds obtained from the results of the study were matched with structures that the target molecules. The antioxidant test using the DPPH method showed that the analogs flavonol derived from 2'-hydroxycalone F7 (31.25 µg / mL) and F9 (35.58 µg / mL) had the potential to be antioxidants. The anticancer test using the MTS method showed that the analog flavonol derived from 2'-hydroxycalone F6 (443.7 µg / mL) was potentially active as an anticancer.. The difference in the position of the subtituent of methoxy (OCH3) in ring B has a considerable influence on the activity as an antioxidant and anticancer.

Key words: 2’-hydroxychalcone, flavonol, 1,1- diphenyl-2-picryl hydrazyl (DPPH, 3- (4,5 dimethylthiazol -2- yl) -5- (3- carboxy methoxyphenyl) -2- (4-sulfophenyl) -2H-tetrazolium (MTS)

Ketersediaan
#
Perpustakaan Universitas Riau 10 05. 219 (0001)
10 05. 219 (0001)
Tersedia
Informasi Detail
Judul Seri
-
No. Panggil
10 05. 219 (0001)
Penerbit
Pekanbaru : Universitas Riau – Pascasarjana – Tesis Kimia.,
Deskripsi Fisik
xiv, 131 hlm.; ill.; 29 cm
Bahasa
Indonesia
ISBN/ISSN
-
Klasifikasi
10 05. 219 (0001)
Tipe Isi
-
Tipe Media
-
Tipe Pembawa
-
Edisi
-
Subjek
PASCASARJANA (MAGISTER) KIMIA
Info Detail Spesifik
-
Pernyataan Tanggungjawab
Versi lain/terkait

Tidak tersedia versi lain

Lampiran Berkas
Komentar
Anda harus masuk sebelum memberikan komentar