CD Tesis

Sintesis, Uji Toksisitas Dan Uji Antioksidan Analog Pirazolin Dari Kalkon 1-Naftaldehid Dan 2-Metoksi Asetofenon

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Two pyrazoline analogs 3- (2-methoxy-phenyl) -5-naphthalene-1-yl-1-phenyl-4,5-dihydro-pyrazole (PF CL-2OMe) and 3-(2-methoxy-phenyl)-5-naphthalene-1-yl-4,5-dihydro-1H-pyrazole (PH CL-2OMe) were synthesized by cyclisation reaction between the (E)-1-(2-methoxy-phenyl)-3-naphthalene-1-yl-propenone (CL-2OMe) and two hydrazine derivatives, phenylhydrazine and hydrazine hydrate using a basic catalyst NaOH. Pyrazoline synthesis with chalcone as intermediate used glacial acetic acid as catalyst and assisted by microwave irradiation. The structure of the compounds were characterized based on the interpretation of UV, FTIR, HRMS, 1H-NMR, 13C-NMR, HSQC, and HMBC spectra. The yield of compound 96.29% (CL-2OMe), 40.95% (PF CL-2OMe), and 41.62% (PH CL-2OMe). Then, to determine the bioactivity of pyrazoline compounds toxicity test and antioxidant activity test. Toxicity tests using the Brine Shrimp Lethality Test (BSLT) method showed that CL-2OMe and PH CL-2OMe were potentially active as anticancer compounds with LC50 values of 0.97 and 228 μg/mL respectively. While the antioxidant test of IC50 value of 8,164.18 μg/mL (CL-2OMe), 10,983.07 μg/mL (PF CL-2OMe), and 4.4731 μg/mL (PH CL-2OMe).

Key words : Chalcone, pyrazoline, microwave irradiation, brine shrimp lethality test (BSLT) and antioxidant.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

10 05. 217 (0010)

Penerbit

Pekanbaru : Universitas Riau – Pasca Sarjana – Kimia., 2017

Deskripsi Fisik

xv, 75hlm.;ill.; 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

10 05. 217 (0010)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PASCASARJANA (MAGISTER) KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

FIKRATUL

Versi lain/terkait

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