CD Tesis

Sintesis Dan Uji Toksisitas Senyawa Analog Kurkumin 1-(3-Kloropropil)-3,5-Bis((E)-4-Metoksi Benziliden)Piperidin-4-On Dan 1-(4-Bromobutil)-3,5- Bis((E)-4 Metoksibenziliden)Piperidin-4-On

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Curcumin is a secondary metabolite that has diverse biological activities. However, curcumin has low bioavailability due to the presence of the β-diketone unit is easily hydrolyzed at physiological pH. Therefore the replacement of the unit with monoketone is expected to overcome this problem. We hereby report the synthesis of the piperidone derivative monoketone curcumin analogs. Synthesis was carried out by Claisen-Schmidt condensation between 4-piperidone with 4-methoxybenzaldehyde using alkaline catalyst in reflux. The curcumin was then reacted with chloropropane and bromobutane linker to produce curcumin 1-(3-chloropropyl)-3,5-bis((E)-4-methoxybenzylidene)piperidine-4-one 11 analog and 1-(4-bromobutyl)-3,5-bis((E)-4-methoxybenziliden) piperidine-4-one 12 with yield of 72 % and 67 %, respectively. The structures of were characterized by using UV spectroscopy, FTIR, 1H NMR, 13C NMR, and HRMS, confirming the compounds according to the target compound. Curcumin compounds were determined their toxicity by using BSLT method. The result showed both compounds were toxic with LC50 values = 93.33 and 104.71 μg/mL, respectively.

Keywords: Curcumin, Synthesis of Curcumin, Toxicity Test (BSLT).

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

10 05. 220 (0005)

Penerbit

Pekanbaru : Universitas Riau – Pascasarjana – Tesis Kimia., 2020

Deskripsi Fisik

vii, 66 hlm.; ill.; 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

10 05. 220 (0005)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PASCASARJANA (MAGISTER) KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

FATAH

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