CD Skripsi

Analisa Ekspresi Gen Untuk Pengujian Efektivitas Pegagan (Centella Asiatica) Sebagai Hepatoprotektor Pada Model Kerusakan Liver Yang Diinduksi Oleh DGalaktosamin/Lipopolisakarida (Lps) Dan Parasetamol

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SUMMARY
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The liver is one of the most vulnerable organs due to its role as the center of metabolism. The use of herbal plants for treating liver damage, such as pegagan (Centella asiatica), has been widely studied. Pegagan, belonging to the Apiaceae family, is easily to find and commonly used as a medicinal source. The topic of this research was gene expression analysis, which is a continuation of research that has been done before regarding testing the effectiveness of pegagan extract as seen from SGPT levels in the blood. In previous studies, pegagan was extracted using a standard formulation with 70% ethanol and 3% asiaticoside was produced. The goal of this study was to proof the effectiveness of the pegagan extract as an anti-inflammatory and antioxidant effects, as observed through a comparison of expression levels of inflammatory and antioxidant genes in each experimental group. The genes analyzed in this study include inflammatory genes such as IL-6, IL-1β, and TNF-α, as well as antioxidant genes such as SOD- 1, HO-1, NQO-1, and NRF2. Additionally, housekeeping genes such as GAPDH and β-actin were also included. The method was used for analyzing genetic expression in this study was qRT-PCR. The qRT-PCR results revealed that the pegagan extract exhibited anti-inflammatory activity but did not show antioxidant activity in the samples induced by d-GalN/LPS. However, in the samples induced by paracetamol, pegagan displayed no anti-inflammatory activity, but it exhibited significant antioxidant activity.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1903112484

Penerbit

Pekanbaru : Universitas Riau - FMIPA - Kimia., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1903112484

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

TETHI

Versi lain/terkait

Lampiran Berkas

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