CD Skripsi

Sintesis Dan Studi Molecular Docking Senyawa Hidrazon (E)-2-((E)-3-(2-Florofenil)-1-(2-Hidroksi Naftalen-1-Il)Alliliden)-N-Fenilhidrazin Karbotioamida Sebagai Antikanker Payudara

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Hydrazone is an organic compound that has an azomethine group –NHN=CH- which has various biological activities, one of which is as an anticancer agent. The hydrazone compound (E)-2-((E)-3-(2-fluorophenyl)-1-(2-hydroxyinaphtalene-1- yl)allylidene)-N-phenylhydrazine carbothioamide has been succesfully synthesized through condensation reaction of the chalcone (6) with 4-phenylthiosemicarbazide using a stirring and heating method in a glass reactor tube. The hydrazone compound (8) obtained was red with a yield percentage of 70.52%. The structure of hydrazone was confirmed through spectroscopic characterization of UV, FTIR, HRMS, 1H-NMR, and 13C-NMR. The pure synthesized compound was tested for it’s activity as an anti-breast cancer agent by molecular docking studies carried out on the estrogen receptor α (PDB ID: 3ERT) with 4-hydroxytamoxifen (4OHT) as natural ligands. The docking results showed that the synthesized hydrazone compound has similar amino acid interaction with 4-OHT, but free bond energy value and inhibition constant of hydrazone compound are -10.58 kcal/mol and 17,55 nM showed hydrazone compound not as effective compared to natural ligand 4-OHT.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1803113436

Penerbit

Pekanbaru : Universitas Riau FMIPA Kimia., 2024

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1803113436

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

mardiah

Versi lain/terkait

Lampiran Berkas

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