CD Skripsi
Isolasi Dan Uji Toksisitas Senyawa Alkaloid Dari Daun Ceriman (Monstera Deliciosa Liebm)
Monstera deliciosa Liebm is a species of flowering plant native to the tropical rainforests of Southern Mexico, Southern Colombia. This plant is rich in secondary metabolites such as alkaloids, flavonoids, saponins and steroids, antimicrobial compounds and antioxidant compounds, and can also be used as a drug for several types of cancer. This research aims to isolate and test the toxicity of alkaloid compounds in ceriman leaves (M. deliciosa Liebm). The sample was macerated using methanol solvent, then partitioned with n-hexane and ethyl acetate solvents. Isolation of alkaloid compounds was carried out using gravity column chromatography to obtain 9 fractions. In fraction 1 (F1) black crystals were obtained with a melting point of 206-208oC and were given the code MDA-F1. The UV-Vis spectrum results show a maximum absorption at a wavelengths of 405, 339, 228 and 203 nm. FT-IR spectra were obtained at wave numbers 3290 cm-1 (N-H), 2956-2851 cm-1 (C-H), 1736 cm-1 (C=O) 1718 cm-1 (C=N), 1600 and 1509 cm-1 (C=C), 1260 cm-1 (C-O) and 1168 cm-1 (C-N). The results of the alkaloid extract toxicity test with an LC50 value of 0.5 ppm showed that the compounds obtained were very toxic.
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