CD Tesis

Uji Antimalaria Dari Alkaloid Kulit Batang Medang Lendir (Litsea Glutinosa(Lour.) C.B.Rob)

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Malaria is a deadly and serious disease caused by Plasmodium falciparum infection which is spreaded by female Anopheles mosquitoes. Some research to get antimalarial drugs being done continuously, since many cases showed of drugs resistance, one of them discovery of antimalarial agents from natural products compounds. Litsea glutinosa is known in the local community as medang lendir. It is species of the family Lauraceae. In the Kampar Kiri Hulu, Kabupaten Kampar Districts, Riau Province, medang lendir is used as anti-mosquitos by burning the the barks. Phytochemical tests on the stem baks showed the presence of secondary metabolite in the form of alkaloid. This research to determine in vitro antimalarial activity of the Litsea glutinosa stem barks. The pure alkaloid isolate were analyzed using UV-Vis, FT-IR, NMR dan HR-MS spectroscopy, showed that compound is aromatic alkaloid marked by presence an amine group (N-H), alkene bond (C=C), 1 methoxy group (-OCH3), 2 primary carbon atoms (-CH3), 10 tertiary carbon atoms (-CH) and 5 quaternary carbon atoms, with molecular mass 476 g/mol. Antimalarial activity assay showed IC50>10 μg/mL. Therefore it can be concluded that the LH-F3 compounds have good potential as antimalarial agent.
Key words: Litsea glutinosa, alkaloid, antimalaria assay

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

10 05. 220 (0012)

Penerbit

Pekanbaru : Universitas Riau – Pascasarjana – Tesis Kimia., 2020

Deskripsi Fisik

xii, 46 hlm,; ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

10 05. 220 (0012)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

FATAH

Versi lain/terkait

Lampiran Berkas

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