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Sintesis Senyawa Kurkumin Dari Turunan 4-Piperidon Tersubsitusi Morfolin Dan Potensinya Sebagai Inhibitor Protease Dengue

Curcumin is a secondary metabolite that has been widely used as traditional medicine, one of which is as antiviral. Curcumin is a β-diketone compound which is relatively unstable and has a low bioavailability. Thus mono-carbonyl curcumin is synthesized to increase its activity and bioavailability. Modification by adding nitrogen containing moiety such as morpholine as well as piperidone group is alleged to increase its antiviral activity. This research aims to synthesize 3,5-Bis ((E)-4-methoxybenziliden)-1-(2-morpholinoethyl) piperidin-4-on a mono-carbonyl curcumin compound and to know its antiviral activity against DENV2, which is the most prevalent strain of Denque Fever virus in South East Asia.
The target compound was synthesized through 2 stages of reactions. The first stage is a substitution reaction between 4-piperidone monohydrate chloride with 4-(2-chloroethyl) morpholine in alkaline conditions. The second stage is reacting the intermediate compound produced in the first reaction with 4-(4) Methoxybenzaldehyde through an aldol condensation reaction. The structure of the compounds was confirmed through UV, IR, HRMS and NMR spectrum analysis. Its antiviral activity was evaluated by molecular docking simulation against NS2B/NS3 DENV2 protease (PDB ID: 2FOM) using Molecular Operating Environment 2019.0102 (MOE) and High Throughput Screening (HTS). As a conclusion this compound have 39.09% inhibitor activity against NS2B/NS3 protease of DENV2.
Keywords: Curcumin, Dengue, Moleculer Docking, NS2B/NS3 protease

Ketersediaan
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Perpustakaan Universitas Riau 10 05. 220 (0014)
10 05. 220 (0014)
Tersedia
Informasi Detail
Judul Seri
-
No. Panggil
10 05. 220 (0014)
Penerbit
Pekanbaru : Universitas Riau – Pascasarjana – Tesis Kimia.,
Deskripsi Fisik
xiv, 56 hlm,; ill.: 29 cm
Bahasa
Indonesia
ISBN/ISSN
-
Klasifikasi
10 05. 220 (0014)
Tipe Isi
-
Tipe Media
-
Tipe Pembawa
-
Edisi
-
Subjek
KIMIA
Info Detail Spesifik
-
Pernyataan Tanggungjawab
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Tidak tersedia versi lain

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