CD Skripsi

Sintesis Dan Uji Toksisitas 4-(3-(4-Fluorofenil)-5-(2-Metoksifenil)-4,5-Dihidro-1h-Pirazol-1-Il)Benzensulfonamida

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SUMMARY
Pyrazoline is a five ring compound with two heteroatoms that have various
biological activities such as anti-inflammatory, antimicrobial, antidiabetic,
antimalarial, anticancer, and antioxidant. This study aims to synthesize pyrazoline
compounds and test activity. Pyrazoline analog 4-(3-(4-fluorophenyl)-5-(2-
methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-yl)benzensulfonamide was obtained
of chalcone (E)-1-(4-fluorophenyl )-3-(2-methoxyphenyl)prop-2-en-1-one and 4-
hydrazine benzensulfonamide by reflux method at 800C. Chalcone compound was
synthesized by an aldol condensation reaction of 4-fluoroacetophenone and 2-
methoxybenzaldehyde. The purity of the compound was determined by TLC ,
melting point and HPLC. The structure of the synthesized compound was
confirmed by spectroscopic analysis of UV, FTIR, 1H-NMR,and HRMS. The
toxicity of pyrazoline compounds was tested by the Brine Shrimp Lethality Test
(BSLT) method using Artemia salina . The pyrazoline compound obtained is nontoxic
with LC50 value >1000 g/mL

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1703122425

Penerbit

Pekanbaru : Universitas Riau - FMIPA -KIMIA., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1703122425

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

tethi

Versi lain/terkait

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