CD Skripsi
Polimorfisme Gen Rvd Bsmi Pada Dewasa Muda Dengan Obesitas Sentral
ABSTRACT
VDR GENE BsmI POLYMORPHISM IN YOUNG ADULTS WITH CENTRAL OBESITY
By
JUNITA SARI
Central obesity is the accumulation of fat with characteristics around the abdomen or abdominal cavity. Obesity has a relationship with vitamin D deficiency which is one of the factors in the occurrence of obesity and increased waist circumference. The active metabolite form of vitamin D is calcitriol, which is mediated by vitamin D receptors (VDR). This study aimed to describe at the VDR gene BsmI polymorphism in young adults with central obesity. This study method is descriptive with the Multiplex amplification refractory mutation system polymerase chain reaction (ARMS-PCR) technique to detect the genotype and alleles of BsmI polymorphism. The study used blood samples, as many as 52 samples that met the inclusion and exclusion criteria. In 52 respondents were found to be centrally obese as many as 37 people (71.2%) and non-central obesity 15 (28.8%). The most BsmI polymorphism genotypes in central obesity were bb 34 (91.9%) and in non-central obesity bb 13 (86.7%). The most alleles in central obesity were b 69 (93.2%) and non-central obesity b 27 (90%).
Keywords: BsmI, Central obesity, Polymorphism, VDR
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