CD Skripsi

Analisis Bioinformatika Komponen Selular Sel Epitel Serviks Pada Pasien Karsinoma Serviks Yang Terinfeksi HPV 16 dan 18

---

Cervical carcinoma is known as a carcinoma disease with a high mortality rate in females due to infection from the HPV virus. It has been found that the type of HPV virus infecting individuals affects the prognosis, where patients infected with HPV- 16 have a better prognosis compared to those infected with HPV-18. There is a suspected connection between patient prognosis and the host cell gene expression. Bioinformatics analysis was performed on three gene expression datasets (GSE121666, GSE9750, GSE6791) using GEO2R and volcano plots to identify gene expression differences between the two HPV types. Over-representation analysis (ORA) was used to analyze expression differences based on cellular components. From the analysis, seven cellular components were found to undergo significant changes, with the Golgi lumen being the most significantly altered. Seven genes contributing to this cellular component were identified: MUC21, MUC5B, MUC6, PCSK6, PDGFA, PDGFB, and WNT6. The expression of MUC21 and MUC5B were higher, while the expression of MUC6, PCSK6, PDGFA, PDGFB, and WNT6 were lower in patients infected with HPV-16 compared to HPV-18. In this research, differences in the gene expression of cellular components were found between cervical carcinoma patients infected with HPV-16 and those with HPV-18. The expression of these genes needs to be confirmed in clinical samples to determine their correlation with the prognosis of cervical cancer patients.

---

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

2008113763

Penerbit

Pekanbaru : Universitas Riau - FK – Pendidikan Dokter., 2024

Deskripsi Fisik

-

Bahasa

Indonesia

ISBN/ISSN

-

Klasifikasi

2008113763

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

PENDIDIKAN DOKTER

Info Detail Spesifik

-

Pernyataan Tanggungjawab

Jaka

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar