CD Skripsi

Proteksi Ekstrak Buah Seri (Muntingia calabura) Terhadap Gambaran Histopatologi Steatosis Hepar Tikus Yang Diinduksi Diet Tinggi Lemak

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Nonalcoholic fatty liver disease (NAFLD), also known as steatosis, is a liver disease that may develop due to obesity and diabetes mellitus. Various approaches are being explored to treat steatosis, including studies on medicinal plants like the cherry fruit (Muntingia calabura). This fruit has antioxidant and anti-inflammatory properties due to its high levels of flavonoids, tannins, saponins, terpenoids, and polyphenols. The objective of this research is to evaluate the effects of cherry fruit on the liver's histopathology in rats induced with fatty liver disease. The study follows an experimental design with a post-test only control group, dividing the rats into four treatment groups: negative control, high-fat diet, cherry fruit extract, and pioglitazone treatment. The negative control group received a standard diet, while the high-fat diet group was fed a high-fat diet. The group receiving the cherry fruit extract was given both a high-fat diet and 100 mg/kgBW of the extract, and the pioglitazone group received a high-fat diet plus pioglitazone. These treatments lasted for 8 weeks. Liver tissue analysis for steatosis was performed microscopically, using the NAFLD Activity Score (NAS). The data were analyzed with non-parametric Kruskal-Wallis then continue with post hoc Mann-Whitney tests via SPSS. The findings revealed that cherry fruit extract (Muntingia calabura) reduced the occurrence of steatosis in the liver of rats induced with fatty liver disease.

Keywords: NAFLD, cherry fruit extract, Muntingia calabura, steatosis

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2108112245

Penerbit

Pekanbaru : Universitas Riau FK Pendidikan Dokter., 2024

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2108112245

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN DOKTER

Info Detail Spesifik

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Pernyataan Tanggungjawab

Jaka

Versi lain/terkait

Lampiran Berkas

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