CD Skripsi

Hubungan Deteksi Biofilm Dengan Uji Kepekaan Antibiotik Pada Isolat Klinis Bakteri Burkholderia Pseudomallei Di Provinsi Riau

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Burkholderia pseudomallei is a pathogenic bacterium responsible for melioidosis, often associated with high mortality rates. Biofilm formation is a key factor in bacterial persistence and resistance to treatment. This study aims to investigate the relationship between biofilm detection and antibiotic susceptibility patterns in clinical isolates of B. pseudomallei in Riau Province. An experimental design was employed with 11 B. pseudomallei isolates collected from the Faculty of Medicine, Universitas Riau. Antibiotic susceptibility was tested using the Kirby-Bauer disk diffusion method, while biofilm production was assessed through adherence quantitative assays. Bivariate analysis was conducted to explore the correlation between biofilm production and antibiotic resistance patterns. Biofilm detection revealed that of the 11 isolates, 10 isolates produced biofilm (90.9%) with 60% of the isolates producing strong biofilm, 20% showed moderate and weak biofilm production respectively. Antibiotic susceptibility testing showed that the highest sensitivity was observed for meropenem (90.9%), the highest intermediate was trimethoprim/sulfamethoxazole and ceftazidime 9 (81.8%), and the highest resistance was amoxicillin/clavulanic acid 4 (36,5%). Then, p value >0.05 was found for the relationship between biofilm detection and antibiotic susceptibility testing on meropenem, trimethoprim/sulfamethoxazole, ceftazidime, and amoxicillin clavulanate. Meanwhile, for the statistical test results of the relationship between biofilm detection and the combined susceptibility test for all antibiotics, the p value was

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2108110402

Penerbit

Pekanbaru : ., 2024

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2108110402

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN DOKTER

Info Detail Spesifik

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Pernyataan Tanggungjawab

Jaka

Versi lain/terkait

Lampiran Berkas

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