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Hubungan Deteksi Biofilm Dengan Resistensi Antibiotik Pada Isolat Klinis Bakteri Penyebab Empiema di Provinsi Riau

Empyema is a global health issue with high incidence, mortality, and morbidity rates. Biofilm formation by bacteria causing empyema is a major factor in the persistence of infections and resistance to treatment. This study aims to analyze the relationship between biofilm detection and antibiotic resistance in bacterial isolates causing empyema in Riau Province. A total of 12 bacterial isolates were collected from the Faculty of Medicine, Universitas Riau. Antibiotic susceptibility testing was performed using the Kirby-Bauer disk diffusion method to identify multidrug-resistant organisms (MDRO), while biofilm production was assessed quantitatively.The results showed that 11 isolates (91.7%) produced biofilm, with 6 isolates (54.5%) producing moderate biofilm and 5 isolates (45.5%) producing weak biofilm. One isolate (8.3%) did not produce biofilm, identified as Staphylococcus aureus. Five isolates (41.7%) were identified as MDRO, while 7 isolates (58.3%) were classified as non-MDRO. No significant correlation was found between biofilm production and antibiotic resistance patterns or MDRO status. These findings differ from previous studies, which suggested that biofilm formation could enhance antimicrobial resistance through specific gene regulation. This study highlights the high prevalence of biofilm among bacterial isolates in Riau, although it does not directly impact antibiotic resistance patterns.The findings emphasize the importance of monitoring antibiotic use based on local resistance patterns and strengthening antimicrobial stewardship programs to prevent the escalation of bacterial resistance in the future.

Keywords: Empyema, bacteria causing empyema, biofilm detection, antibiotic resistance, multidrug-resistant organism (MDRO), Riau Province

Ketersediaan
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Perpustakaan Universitas Riau 2108156588
2108156588
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Informasi Detail
Judul Seri
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No. Panggil
2108156588
Penerbit
Pekanbaru : Universitas Riau FK Pendidikan Dokter.,
Deskripsi Fisik
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Bahasa
Indonesia
ISBN/ISSN
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Klasifikasi
2108156588
Tipe Isi
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Tipe Media
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Tipe Pembawa
-
Edisi
-
Subjek
PENDIDIKAN DOKTER
Info Detail Spesifik
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Pernyataan Tanggungjawab
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Tidak tersedia versi lain

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