CD Tesis

Hubungan Kadar Malonidaldehid (MDA) dengan Peningkatan ENZIM Hati Pada Pasien Tuberkulosis yang Mendapat Terapi Obat Anti Tuberkulosis Kombinasi Dosis Tetap (OAT KDT) Di RSUD Arifin Achmad Provinsi Riau

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Introduction:Tuberculosis (TB) is an infectious disease caused by Mycobacterium
Tuberculosis. The incidence of hepatotoxicity in TB patients due to anti-tuberculosis
drugs (OAT) ranges from 5-28% of patients. Hepatotoxicity can affect the success of
TB treatment until death, therefore OAT hepatotoxicity must be addressed as early as
possible. Infecting tuberculosis causes inflammation and triggers oxidative stress
which is the result of an imbalance between Reactive Oxygen Species (ROS) and
antioxidant mechanisms in the lung. Constant reactive oxygen species can lead to lung
dysfunction. The use of OAT can also increase the production of ROS or free radicals
that cause damage to hepatocyte cells that cause Drug Induced Liver Injury.
Malondialdehyde is the most widely studied lipid peroxidation product and is used as
a biochemical marker for oxidative stress assessment. Various research reports show
MDA values are directly proportional to the increase in liver function biomarkers due
to increased oxidative stress which can be measured quantitatively.
Methods: This study is an observational analytic study with a cohort design conducted
at Arifin Achmad Hospital from December 2023 to March 2024 in the early phase of
treatment with OAT KDT. A total of 35 TB patients who met the inclusion criteria
were examined for MDA enzyme levels using ELISA and liver function biomarkers at
the beginning of treatment and at the end of the second month of treatment or when
there was an improvement in liver function. Then assessed whether there is a
relationship between MDA levels and the increase in liver function biomarker values.
Results: Based on the results of this study, liver function and MDA levels of TB
patients before and after OAT consumption have a significant difference between liver
function data and MDA levels of TB patients before and after taking OAT where the p
value 0.05.
found that increased MDA levels did not have a significant relationship with the
incidence of impaired liver function.
Conclusion: Increased MDA levels have no association with the incidence of liver
function disorders in tuberculosis patients using KDT OAT at Arifin Achmad Hospital,
Riau Province.
Keywords: Tuberculosis, Free Radical, MDA

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2010241697

Penerbit

Pekanbaru : Universitas Riau – Pascasarjana – Pulmonologi dan Ilmu Kedokteran Respirasi., 2025

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2010241697

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Pulmonologi dan Ilmu Kedokteran Respirasi

Info Detail Spesifik

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Pernyataan Tanggungjawab

Jaka

Versi lain/terkait

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