CD Skripsi

Sintesis Dan Uji Toksisitas Senyawa Analog Kalkon Turunan 3’-Hidroksi Asetofenon

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Chalcone is one of secondary metabolites of flavonoids that have been reported to possess biological activities such as antioxidant, antimicrobial, and anti-inflammatory. Three chalcone analogues i.e., (E)-3-(2,3-dimethoxysiphenyl)-1-(3’-hidroxyphenyl)prop-2-en-1-one (EK-1), (E)-3-(2,5-dimethoxysiphenyl)-1-(3’-hidroxyphenyl)prop-2-en-1-one (EK-2), (E)-1-(3’-hidroxyphenyl)-3-(3,4,5-trimethoxysiphenyl)prop-2-en-1-one (EK-3) were synthesized under microwave irradiation using base catalyst (KOH). The compounds structure were than characterized based on the interpretation of spectroscopic data included UV, IR, 1H-NMR, and MS. The toxicity of these chalcones were determined using the Brine Shrimp Lethality Test method againts larvae of Artemia salina Leach. Our finding showed that LC50 of EK-1, EK-2, EK-3 was 185.35 μg/mL; 135.21 μg/mL; and 408.32 μg/mL respectively. The result showed that EK-1 and EK-2 were potential as anticancer since their LC50 were less than 200 mg/mL.
Key words: Brine Shrimp Lethality Test, chalcone, microwave

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 115 (0078)

Penerbit

Pekanbaru : Universitas Riau - FMIPA - Kimia., 2015

Deskripsi Fisik

xiii, 39 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 115 (0078)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Dewa

Versi lain/terkait

Lampiran Berkas

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