CD Skripsi

Sintesis Dan Uji Toksisitas Analog Pirazol 3-(4-Klorofenil)-5-(4-Metoksifenil)-1-Fenil-Pirazol

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ABSTRACT

Pyrazole is an important group of five ring heterocyclic compounds containing two adjacent nitrogen atoms which have a diverse biological activities such as antiviral, anti-inflammatory, antioxidant and antimicrobial. Pirazol analogue 3-(4-chlorophenyl)-5-(4-metoxyphenyl)-1-phenyl-pyrazole (TFP-4Cl-4OMe) was syn-thesized via oxidative aromatization reaction of pyrazoline with glacial acetic acid. Pyrazoline and pyrazol were synthesized by microwave at 180 W and reflux at temperature 85oC. The yield obtained from the synthesis of PF-4Cl-4OMe and TFP-4Cl-4OMe compound was 45,78% and 62.26%. Purity of the compounds were checked on TLC plates, melting point and HPLC analysis. The structure of synthesized compounds were confirmed by UV, FTIR, NMR and HRMS spectroscopy studies.The result UV spectroscopy of both compounds showed pyrazoline has three peaks is highest than pyrazol. In FTIR spectroscopy showed a there were do not has signifcant differents between the both compounds. While the NMR spectroscopy showed the difference in peak H-1 signal in both of these compounds. The toxicity of pyrazoline and pyrazol were evaluated with shrimp larvae (Artemia salina Leach). Pyrazoline PF-4Cl-4OMe is non-toxic as LC50 showed 301.30 µg/mL because the value of LC50 pyrazolin is greater than 200 µg/mL, while pyrazole TFP-4Cl-4OMe showed high toxicity with LC50 = 177.011 µg/mL because the value of LC50 is less than 200 µg/mL.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02.118 (0099)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2018

Deskripsi Fisik

xiii, 40 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02.118 (0099)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

JAKA

Versi lain/terkait

Lampiran Berkas

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