CD Skripsi

Sintesis Dan Uji Toksisitas Senyawa 5-(3-Fluorofenil)-3-(Naftalen-2-Il)-1-Fenil- 1h-Pirazol

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Pyrazole is an important group of five circular heterocyclic compounds containing nitrogen atoms which are included in the alkaloid group of secondary metabolites. Apart from containing two adjacent nitrogen atoms, pyrazole compounds also have two endocyclic double bonds. These this compound has interesting biological activities such as, anticancer, antitumor, antiinflammatory and antioxidant. In this study, the pyrazole analogue 5-(3-fluorophenyl)-3-(naphthalene-2-yl)-1-phenyl-1H-pyrazole (PZL 2N-3F) was successfully synthesized through the synthesis of one-pot cyclization of pyrazoline which was then continued. By oxidative aromatization reaction of pyrazoline 5-(4-fluorophenyl)-3-(naphthalene2-yl)-1-phenyl-4,5-dihydro-1H-pyrazole with glacial acetic acid under reflux for 42 hours. The purity of the synthesized compound was determined using the TLC, melting point and HPLC analysis. Structure identification was carried out through spectroscopic analysis of UV, FTIR, NMR and HRMS. The yield obtained from the synthesis of PZL 2N-3F compound was 14.8%. The toxicity of pyrazole compounds was determined by the BSLT method using shrimp Larvae (Artemia salina Leach). The results of the BSLT for the PZL 2N-3F compound were non-toxic with an LC50 value of = 606.7 µg/mL.

Keyword: Brine Shrimp Lethality Test, pyrazole, pyrazoline, reflux, toxicity

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 120 (0072)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2020

Deskripsi Fisik

xiii, 44 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 120 (0072)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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