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Hubungan Antara Polimorfisme Gen Interleukin-10 (-819) Dengan Kerusakan Hati Pada Pasien Hepatitis B Kronik Di Rsud Arifin Achmad Provinsi Riau

Chronic hepatitis B is a global health problem. Chronic hepatitis B (CHB) patients
are at risk of fatal liver diseases such as cirrhosis of the liver and hepatocellular
carcinoma (HCC). Hepatitis B virus (HBV) is a non-cytopathic virus which means
the liver damage is not caused by the virus itself but associated with the immune
response against the infected hepatocytes. Interleukin-10 (IL-10) is an antiinflammatory
cytokine that plays an important role in regulating inflammatory
reactions and maintaining organ functions. This study aimed to determine the
relationship between the IL-10 (-819) gene polymorphisms and liver damage in
chronic hepatitis B patients at Arifin Achmad District Hospital, Riau Province.
Study subjects was recruited from October to December 2019. This study included
74 CHB patients aged 45.4713.42 years old, consisting of 43 (58.1%) men and 31
(41.9%) women. Liver damage was examined based on alanine aminotransferase
(ALT) levels. The identification of the IL-10 (-819) gene polymorphisms was
carried out by the Amplification Refractory Mutation System - Polymerase Chain
Reaction (ARMS-PCR) method. The results showed that the genotype of IL-10 (-
819) gene polymorphism among the study subjects predominantly belonged to CT
genotype (45.9%), followed by TT genotype (40.5%) and CC genotype (13.5%).
Most of CHB patients demonstrated normal levels of serum ALT (86.5%).
Statistical analysis revealed that there was no significant relationship between IL-
10 gene polymorphism (-819) and liver damage in chronic hepatitis B patients at
the Arifin Achmad District Hospital, Riau (p>0.05).
Keywords : Chronic hepatitis B, liver damage, IL-10 (-819) gene polymorphism

Ketersediaan
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Perpustakaan Universitas Riau 08 01.121 (0053)
08 01.121 (0053)
Tersedia
Informasi Detail
Judul Seri
-
No. Panggil
08 01.121 (0053)
Penerbit
Pekanbaru : Universitas Riau – Kedokteran – Pendidikan Dokter.,
Deskripsi Fisik
xiv, 47 hlm.: ill.: 29 cm
Bahasa
Indonesia
ISBN/ISSN
-
Klasifikasi
08 01.121 (0053)
Tipe Isi
-
Tipe Media
-
Tipe Pembawa
-
Edisi
-
Subjek
PENDIDIKAN DOKTER
Info Detail Spesifik
-
Pernyataan Tanggungjawab
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Tidak tersedia versi lain

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