CD Skripsi

Hubungan Faktor Risiko Dengan Kanker Endometrium Berdasarkan Ekspresi Reseptor Estrogen

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Endometrial cancer (EC) is one of the most common malignancies affecting the female reproductive system. Elevated levels of estrogen unopposed by progesterone can stimulate endometrial cell proliferation and increase the risk of EC. Several risk factors such as parity, obesity, hypertension, and diabetes mellitus contribute to this hormonal imbalance in the pathogenesis of EC. Estrogen receptor expression serves as an important indicator for determining EC subtype and guiding hormonal therapy. This study aimed to investigate the relationship between the risk factors parity, obesity, hypertension, and diabetes mellitus and EC based on estrogen receptor expression at Arifin Achmad Regional Hospital from January 2019 to October 2024.This was an analytic observational study with a cross-sectional design, supplemented by laboratory analysis. The study population included the entire medical record dataset of EC patients who underwent hysterectomy between January 2019 and October 2024, from which a total of 44 patients were sampled. Immunohistochemical evaluation of the paraffin-embedded tissue blocks was carried out using estrogen receptor antibodies, and receptor expression was assessed using the Allred scoring system.The patient distribution showed that the majority were estrogen receptor–positive (79.5%), multiparous (62.9%), obese (82.9%), non-hypertensive (68.6%), and non-diabetic (57.1%). Bivariate analysis revealed no statistically significant associations between estrogen receptor expression and parity (p = 0.316), obesity (p = 0.283), hypertension (p = 0.222), or diabetes mellitus (p = 0.077). In conclusion, patients with positive estrogen receptor expression may be candidates for hormone-based therapy.

Keyword : Endometrial cancer, estrogen receptor, risk factor

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2108110395

Penerbit

Pekanbaru : Universitas Riau - Kedokteran - Pendidikan Dokter., 2025

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2108110395

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN KEDOKTERAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

Vina

Versi lain/terkait

Lampiran Berkas

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