CD Skripsi

Sintesis Pirazolin Dari Kalkon 3-Kloro Inti Naftalen Dan Uji Aktivitasnya Sebagai Antibakteri

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ABSTRACT
Pyrazolines have been reported to possess many of interesting biological activities
such as antimicrobial, antidepressant, antitumor, antioxidant, anti-inflammatory,
anticancer and anticonvulsant. Two of analog pyrazolines 1-phenyl-
3-(1-naphthyl)-5-(3-chlorophenyl)-2-pyrazoline (AR1) and 1-phenyl-
3-(2-naphthyl)-5-(3-chlorophenyl)-2-pyrazoline (AR2) were synthesized by
cyclization of chalcones and phenylhydrazine using glacial acetic acid as catalyst
with microwave irradiated. The stuctures of all compounds were characterized
based on the interpretation of spectroscopic data including UV, IR, 1H-NMR,
13C-NMR and COSY. The compounds AR1 and AR2 showed yield 54,27% and
34,19%. Antibacterial activity of pyrazolines was determined using agar diffusion
method against Gram positive bacteria (B. subtilis and S. aureus) and Gram
negative bacteria (E. coli and S. typhi). The compound AR1 not showed
antibacterial activity against tested bacteria. The compound AR2 showed very
poor activity against S. typhi.
Keywords: Antibacterial activity, chalcones, phenylhydrazine, pyrazolines.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 114 (0096)

Penerbit

Pekanbaru : Universitas Riau – FMIPA– Kimia., 2014

Deskripsi Fisik

ix, 79 hlm.; ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 114 (0096)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Daus

Versi lain/terkait

Lampiran Berkas

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