CD Skripsi

Analisis Hubungan Ekspresi Gen MSH3 Dengan Gambaran KlinisPasien Karsinoma Endometrial

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ABSTRACT

Endometrial carcinoma (EC) is a malignancy of the deepest epithelial cells layer of the uterine. Failure of DNA repair system such as mismatch repair (MMR) is a predisposing factor of EC. The MutS homolog 3 (MSH3) gene is one of the MMR genes that will correct microsatellite instability (MSI) which is reported in EC. The aim of this study is to investigate the expression of MSH3 gene and clinical profile in EC patients. This study used an observational analytical method with a cross sectional design. Tissues, MSH3 gene expression, and clinical profiles data was downloaded from database TCGA TARGET GTEx, GDC TCGA UCEC, TCGA-UCEC, and cBioPortal via https://xenabrowser.net/. The univariate analysis used to described the clinical profiles of EC patients. Bivariate analysis (Independent T-test, Mann Whitney, One Way Anova, and Kruskall Wallis statistic) used to analyzed the association of MSH3 gene expression with clinical profiles of EC patients. The results reported that the most clinical profile of EC patients are age ≥61 years old (62,1%), early stage (71,5%), grade 3 (59,1%), histopathological type II (59,7%), and copy number low (39,1%). MSH3 gene expression in EC tissues higher than normal endometrial tissues (8,97 vs 8,44 tpm). MSH3 gene expression in grade 3 higher than grade 1 (8,84 vs 8,43 tpm). MSH3 gene expression in histopathological type II higher than type I (8,86 vs 8,50 tpm). In conclusion, MSH3 gene expression higher in EC tissues, grade 3 and type II.

Keywords : Clinical profiles, endometrial cancer, gene expression, MSH3

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2008113772

Penerbit

Pekanbaru : Universitas Riau - FK – Pendidikan Dokter., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2008113772

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN DOKTER

Info Detail Spesifik

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Pernyataan Tanggungjawab

Jaka

Versi lain/terkait

Lampiran Berkas

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