CD Skripsi

Analisis Bioinformatika Ekspresi Gen Sel Epitel Serviks Pada Karsinoma Serviks Yang Terinfeksi HPV-16 dan HPV-18 Berdasarkan Fungsi Molekuler

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ABSTRACT
Cervical carcinoma is an epithelial malignancy in the cervix, primarily caused by HPV infection. The main HPV types responsible for cervical carcinoma are HPV-16 and HPV-18. Between these two infections, there are differences in distribution and prognosis in cervical carcinoma. This study identifies differentially expressed genes between HPV-16 and HPV-18 infections based on their molecular functions. Three gene expression profiles (GSE151666, GSE9750, and GSE6791) were downloaded and filtered from the GEO database. Differentially expressed genes were obtained through GEO2R analysis and volcano plot visualization. Over-Representation Analysis (ORA) analysis was performed on the identified genes to categorize them into molecular function-based gene groups. A total of 10 molecular functions were identified, with monooxygenase activity being the most significant. Genes contributing to monooxygenase activity include AKR1C1-AKR1C4, CYP2B6, CYP2W1, and FMO3. There was an increase in the expression of AKR1C1-C4, CYP2B6, and FMO3 genes and a decrease in CYP2W1 gene expression in HPV-16 infection compared to HPV-18. This study indicates the presence of different mechanisms between HPV-16 and HPV-18 infections, but it requires validation through experimental research.

Keyword: Bioinformatics analysis, cervical carcinoma, differential expression gene, human papillomavirus, molecular function.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2008126345

Penerbit

Pekanbaru : Universitas Riau - FK – Pendidikan Dokter., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2008126345

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN DOKTER

Info Detail Spesifik

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Pernyataan Tanggungjawab

Jaka

Versi lain/terkait

Lampiran Berkas

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