CD Disertasi

Sintesis Analog Kurkumin Monoketon Pirazolopiridin, Serta Aktivitas Anti Inflamasinya Secara In Vivo Dan In Silico

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Pyrazolopyridines are one of the most widely developed basic materials among various N-heterocyclics, and are able to play multiple roles in different pathophysiological conditions, so they are often considered as the backbone in the synthesis and design of new drugs. The aim of this research is to synthesize new pyrazolopyridine compounds and analyze it by UV, IR and 1H-NMR spectrophotometry and molecular docking. The best docking results were carried out using an in vivo subplantar anti-inflammatory test on the feet of male white rats (Rattus novergicus). Molecular synthesis was carried out using the Claisen-Scmhidt reaction through the condensation of substituted benzaldehyde and 4-piperidone derivatives to produce a monoketone curcumin analogue, then cyclized with phenyl hydrazine. The synthesis results were analyzed by molecular docking on the 3LN1 protein with MOE 2019.0901 (licensed). Next, an in vivo anti-inflammatory test was carried out using a pleitismometer. The synthesis results obtained 13 pyrazolo-pyridine compounds with 7 molecules being new compounds. In vivo anti-inflammatory test, the 3 best compounds were active as anti-inflammatories. The synthesis results obtained 13 pyrazolopyridine molecules and 7 molecules were new compounds. Compounds 5, 7 and 12 show good potential as active anti-inflammatories against COX-2 and interleukins. The best in vivo test result was compound 12. The synthesis results obtained were 13 pyrazolopyridine molecules with 7 molecules are new compounds, and the best in vivo anti-inflammatory test was compound 12 which was a new compound.

Keywords: Pyrazolopyridine, Claisen-Scmhidt, molecular docking, antiinflammatory

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1710346336

Penerbit

Pekanbaru : Universitas Riau – FMIPA – S3 (Disertasi) Ilmu Kimia., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1710346336

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

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Info Detail Spesifik

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Pernyataan Tanggungjawab

Mutia

Versi lain/terkait

Lampiran Berkas

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