CD Skripsi

Sintesis Analog 2-Pirazolin Dari Kalkon Inti Naftalen Dan Uji Aktivitasnya Sebagai Antibakteri

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Pyrazolines have been reported to possess many of interesting biological activities such as antibacterial, antitumor, antioxidant, anti-inflammatory, antimalarial, anticancer, and anticonvulsant. The compounds of analogues 2-pyrazoline were synthesized by the of cyclization chalcones and hydrazine derivatives. The compound 5-(4-chlorophenyl)-3-(naphthalene-1-yl)-4,5-dihydro-1H-pirazol (FH1) was synthesized by the reaction between 1-naphthyl chalcones and hydrazine hydrate using glacial acetic acid as catalyst under microwave irradiation and the yields is 65.36%. The compounds 5-(4-chlorophenyl)-3-(naphthalene-1-yl)-1-phenyl-4,5-dihydro-1H-pirazol (FH2) was synthesized by the reaction between 1-naphthyl chalcones and fenilhidrazin using glacial acetic acid as catalyst under microwave irradiation and the yields is 45.41%. The stuctures of compounds were characterized base on the interpretation of spectroscopic data including UV, IR, 1H-NMR, and 13C-NMR. The antibacterial activity of pyrazolines was determined using the agar diffusion method againt the bacteria Escherichia coli, Salmonella typi, Bacillus subtilis and Staphylococcus aureus. The antibacterial activity of FH1 and FH2 were classified as very weak at concentrations of 10, 30 and 50 μg/disk with a diameter of inhibition produced is 6,2 – 8,1 mm.
Keywords: 1-naphthyl chalcones, pyrazolines, antibacterial activity, agar diffusion
method.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02.114 (0045)

Penerbit

Pekanbaru : Universitas Riau - FMIPA – Kima., 2014

Deskripsi Fisik

xiii, 34 hlm.;ill.; 29 cm

Bahasa

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Klasifikasi

03 02.114 (0045)

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Tipe Media

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Tipe Pembawa

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Edisi

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Pernyataan Tanggungjawab

Dewa

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