CD Skripsi

Sintesis Dan Uji Toksisitas Senyawa Pirazolin (E)-5-Benzil-7-(4-Klorobenziliden)-3-(4-Klorofenil)-2-Fenil-3, 3a, 4, 5, 6, 7-Heksahidro-2h-Pirazolo [4,3c] Piridin

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ABSTRACT
Pyrazoline is a five-loop compound with two heteroatoms that have various biological activities such as anti-inflammatory, antimicrobial, antidiabetic, antimalarial, anticancer, and antioxidant. This study aims to synthesize pyrazoline compounds by adding variations and increasing their biocativity. Pyrazoline analogue (E)-5-benzyl-7-(4-chlorobenzyliden)-3-(4-chlorophenyl)-2-phenyl-3, 3a, 4, 5, 6, 7-hexahydro-2H-pyrazolo [4, 3c] pyridine was synthesized of curcumin (3E, 5E)-1-benzyl-3, 5-bis (4-kolorobenziliden) piperidine-4-on with phenylhydrazine using sodium hydroxide catalyst in ethanol solvent. Curcumin compounds are obtained from the aldol condensation reaction between 1-benzyl- 4-piperidone and 4-chlorobenzaldehyde using sodium hydroxide catalyst in ethanol solvent. Pyrazoline compounds were synthesized using a sealed vessel reactor the compound was determined by using TLC and melting point. Identification of the structure of pyrazoline compounds by spectroscopic analysis of UV, FTIR, NMR, and HRMS. The yield obtained from the synthesis of pyrazoline compounds was 39,8%. The toxicity of pyrazoline compounds was tested by the BSLT method using A. salina. The test results showed that the pyrazoline compound is non-toxic with a value of LC50 = 792,14 µg/mL.
Keyword: curcumine, pyrazoline, sealed vessel reactor, toxicity

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 121 (0001)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2021

Deskripsi Fisik

v, 107 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 121 (0001)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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