CD Skripsi

Sintesis Kalkon Inti Naftalen Dari Asetilnaftalen Dengan 4-Bromobenzaldehid Dan Uji Aktivitasnya Sebagai Antibakteri

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Two chalcones (E)-3-(4-Bromo-phenyl)-1-naphthalen-1-yl-propenone (RI1) and (E)-3-(4-Bromo-phenyl)-1-naphthalen-2-yl-propenone (RI2) were synthesized by the stirring in Claisen-Schmidt Condensation with NaOH as the catalyst. The structure of the compounds was confirmed by 1H-NMR, 13C-NMR, IR, MS and UV spectroscopy methods. RI1 and RI2 obtained were in 81.9% and 57.4% yields respectively. The synthesized compounds were evaluated for their antibacterial activity by agar diffusion method against Staphylococcus aureus and Bacillus subtilis (Gram-positive bacteria), Escherichia coli and Salmonella enteritidis (Gram-negative bacteria). Both compounds exhibited weak activity against Escherichia coli with 6.1 – 6.4 mm of inhibition zone and no activity against bacteria Staphylococcus aureus, Salmonella Enteritidis and Bacillus subtilis.
Keywords: 1-acethylnaphthalene, 4-bromobenzaldehyde, antibacterial, chalcone

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Ketersediaan

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Judul Seri

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No. Panggil

03 02.114 (0043)

Penerbit

Pekanbaru : Universitas Riau - FMIPA – Kima., 2014

Deskripsi Fisik

xiii, 30 hlm.;ill.; 29 cm

Bahasa

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Klasifikasi

03 02.114 (0043)

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Tipe Media

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