Image of Korelasi Kadar Total Imunoglobulin E Serum dan Eosinofil Absolut Darah Tepi sebagai Faktor Prognostik terhadap Derajat Kontrol Asma pada Pasien Asma Stabil berdasarkan Kuesioner ACT di Poli Paru RSUD Arifin Achmad Provinsi Riau
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Korelasi Kadar Total Imunoglobulin E Serum dan Eosinofil Absolut Darah Tepi sebagai Faktor Prognostik terhadap Derajat Kontrol Asma pada Pasien Asma Stabil berdasarkan Kuesioner ACT di Poli Paru RSUD Arifin Achmad Provinsi Riau

Background :
Immunoglobulin E as a major role in the early reactions of asthma, while eosinophils as a more important role in the late reactions of asthma. Correctly assessing and treating asthma in the early stages especially on serum IgE levels and peripheral blood absolute eosinophil levels will be able to achieve asthma control and reduction of exacerbations based on certain cut-off values.
Method :
This research was conducted from December 2023 to February 2024 involving 37 research subjects. The research subjects were stable asthma patients who came for outpatient treatment at the pulmonary clinic at Arifin Achmad Regional Hospital, Riau Province. This research is a prognostic study using a cross sectional research design.
Results :
This study involved 37 stable asthma patients with a mean age of 45.3 years, mostly female, obese body mass index, bronchodilator test with a VEP1 value>12% and>200 ml from the baseline value, non-smokers, had a genetic history and had comorbidities. Serum total immunoglobulin E levels had a median value of 456 IU/ml (minimum and maximum values 15 IU/ml and 3728 IU/ml) while peripheral blood absolute eosinophil levels had a median value of 289 /uL (minimum and maximum values 17/uL and 956/ml). uL). The highest degree of asthma control based on the initial ACT questionnaire was uncontrolled (ACT score < 19) at 75.7%. There was no statistically significant correlation between total serum immunoglobulin E levels and peripheral blood absolute eosinophil levels as prognostic factors for the degree of asthma control based on ACT. The cut point for total serum immunoglobulin E levels was 70.5 IU/ml with a sensitivity of 96.4% and a specificity of 55.6%, while the cut point for absolute eosinophil levels in peripheral blood was 239 /μL with a sensitivity of 64.3% and a specificity of 55.6 % but this is not statistically significant as a prognostic factor for the degree of asthma control based on ACT.
Conclusion :
There is no significant correlation in total serum immunoglobulin E levels and peripheral blood absolute eosinophils as prognostic factors for the degree of asthma control in stable asthma patients based on the ACT questionnaire

Keywords: Total Serum Immunoglobulin E Levels, Peripheral Blood Absolute Eosinophils, Degree of Asthma Control, ACT Questionnaire

Ketersediaan
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Perpustakaan Universitas Riau 2010241696
2010241696
Tersedia
Informasi Detail
Judul Seri
-
No. Panggil
2010241696
Penerbit
Pekanbaru : Universitas Riau – Pascasarjana – Pulmonologi dan Ilmu Kedokteran Respirasi.,
Deskripsi Fisik
-
Bahasa
Indonesia
ISBN/ISSN
-
Klasifikasi
2010241696
Tipe Isi
-
Tipe Media
-
Tipe Pembawa
-
Edisi
-
Subjek
Pulmonologi dan Ilmu Kedokteran Respirasi
Info Detail Spesifik
-
Pernyataan Tanggungjawab
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Tidak tersedia versi lain

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