CD Skripsi

Sintesis Turunan Kalkon Piridin Dari Asetiltiopen Dan Piridinkarbaldehid Serta Uji Antioksidan Menggunakan Metode Dpph (2,2’-Diphenyl-1-Picrylhydrazyl)

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Chalcone is one of secondary metabolites included into the class of flavonoids that are known to have biological activities. Two compound analogues of condensation reaction have been synthesized using microwave irradiation with a base catalyst and their antioxidant activity were evaluated. Starting material that has been used was pyridinecarbaldehyd as aldehyd in different position and acetylthiophen as ketone. The synthesized compounds were (4-hydroxy-2,6-di (pyridin-3-yl)-4-(thiophen-2-yl) cyclohexane-1,3-diyl) bis (thiophen-2-ylmethanone) (IF1) and (4-hydroxy-2,6-di (pyridin-4-yl)-4-(thiophen-2-yl)cyclohexane-1,3-diyl)bis(thiophen-2-ylmethanone) (IF2). The purity of these compounds have been tested using TLC, melting point test and analytical HPLC. The structures of the synthesized products have been elucidated using IR, 1H- NMR, 13C-NMR and mass-spectroscopic data and elemental analyses. The final products were screened for their antioxidant activity. All the compounds exhibited low DPPH (2,2’-diphenyl-1-picrylhydrazyl) scavenging activity, showed with IC50 > 500 ppm.
Keywords : chalcone, antioxidant, DPPH method, free radical

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02.114 (0090)

Penerbit

Pekanbaru : Universitas Riau - FMIPA – Kima., 2014

Deskripsi Fisik

viii, 42 hlm.;ill.; 29 cm

Bahasa

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Klasifikasi

03 02.114 (0090)

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Tipe Media

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Tipe Pembawa

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Edisi

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Pernyataan Tanggungjawab

Dewa

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