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Sintesis Dan Uji Toksisitas Senyawa Analog Kurkumin 3,5-Bis((E)-Metoksi Benziliden)-1-(Fenilsulfonil)Piperidin-4-On

A study has been conducted to synthesize analog of curcumin with base catalyzed condensation of 4-piperidone hydrochloride with substituted benzaldehyde under reflux led the formation of mono-carbonyl curcumin. The synthesized curcumin were further reacted with benzosulphonyl chloride by nucleophilic substitution of –NH group to afford 3,5-bis((E)-2-metoksi benziliden)-1-(fenilsulfonil)piperidin-4-on (EN1-BS) and 3,5-bis((E)-4-metoksi benziliden)-1-(fenilsulfonil)piperidin-4-on (EN2-BS) compounds with excellent yield, 94% and 88%, respectively. Structure of the synthesized compounds were confirmed using UV, IR, MS and NMR spectra analysis. All the synthesized compounds were screened for their toxicity activity using BSLT method. The result showed that compounds are toxic whereas the LC50 is below 200 ppm.
Keywords: Anticancer, curcumin , monocarbonyl curcumi

Ketersediaan
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Perpustakaan Universitas Riau 10 05. 218 (0007)
10 05. 218 (0007)
Tersedia
Informasi Detail
Judul Seri
-
No. Panggil
10 05. 218 (0007)
Penerbit
Pekanbaru : Universitas Riau – Pascasarjana – Tesis Kimia.,
Deskripsi Fisik
xiii, 76 hlm.; ill.; 29 cm
Bahasa
Indonesia
ISBN/ISSN
-
Klasifikasi
10 05. 218 (0007)
Tipe Isi
-
Tipe Media
-
Tipe Pembawa
-
Edisi
-
Subjek
PASCASARJANA (MAGISTER) KIMIA
Info Detail Spesifik
-
Pernyataan Tanggungjawab
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Tidak tersedia versi lain

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