CD Tesis

Sintesis Dan Uji Bioaktivitas Analog Pirazolin Dari Kalkon 3-Bromo Naftalen

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Pyrazoline compounds known as the azole group which is consist of oxazole, thiazole, imidazole and pyrazole groups. Pyrazoline is obtained by reacting chalcone with phenyl hydrazine or hydrazine hydrate. Pyrazoline synthesis is carried out using microwave irradiation methods which in this case use microwave oven. Synthesis of pyrazoline contain functional groups obtained from chalcone. Functional groups such as flouro, chloro, bromo, nitro, methoxy have an important role in drug design.
In this research pyrazoline compounds were synthesized by reacting 3-bromo naphthalene chalcone with hydrazine hydrate in ethanol through nucleophilic addition reaction using glacial acetic acid as catalyst and using microwave oven method under 300 Watt. Synthesis begins with synthesizing chalcone, namely chalcone (E)-3-(3-bromophenyl)-1- (naphthalene-1-il) prop-2-en-1-on and (E)-3-(3-bromophenyl)-1- (naphthalene-2-il) prop-2-en-1-on from an aldol condensation reaction between acetylnaphthalene and 3-bromobenzaldehyde.
Two pyrazoline analogs PH-CN1-3Br and PH-CN2-3Br were obtained. The compounds were analyzed using UV, IR, MS and NMR spectroscopy to confirm the structure of pyrazoline according to the target molecule. Antimicrobial test of pyrazoline analog shows that both pyrazoline are inactive, whereas both compounds do not show clear zones. While the antioxidant test showed that both analogs of pyrazoline were potential as antioxidant agents with IC50 values of 32.85 μg / mL (PH-CN1-3Br) and 33.69 μg / mL (PH-CN2-3Br).

Keywords: antioxidant, antimicrobial, chalcone, microwave iradiation, pyrazoline.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

10 05. 219 (0005)

Penerbit

Pekanbaru : Universitas Riau – Pascasarjana – Tesis Kimia., 2019

Deskripsi Fisik

xi, 101 hlm.; ill.; 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

10 05. 219 (0005)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PASCASARJANA (MAGISTER) KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

FATAH

Versi lain/terkait

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