Eucheuma spinosum is a type of red algae (Rhodophyta) that contains secondary metabolites that have the potential to be used as bioactive producers as antibacterial. Along with the increase in bacterial resistance to antibiotics, the use of E. spinosum seaweed as a new antibacterial compound was carried out. Bacteria Vibrio alginolyticus and Aeromonas hydrophila are aquatic pathogenic bact…