CD Tesis

Analisis Aktivitas Anti Inflamasi Nanokurkumin Terhadap Ekspresi Il-10 Dan Cox-2 Pada Tikus Model Adenomiosis

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Background: Adenomyosis is a benign gynecological condition characterized by the invasion of endometrial tissue into the myometrium, with a prevalence of 10-65% in women of reproductive age. Its symptoms include dysmenorrhea, heavy menstrual bleeding, and infertility, all of which significantly impact the quality of life. Chronic inflammation plays a key role in its pathogenesis, marked by increased inflammatory mediators such as IL-6, TNF-α, and COX-2. Curcumin has anti-inflammatory properties through the inhibition of NF-κB and COX-2 pathways and modulation of IL-10. With higher bioavailability, nanocurcumin is expected to provide significant therapeutic effects on adenomyosis. This study analyzes the anti-inflammatory activity of nanocurcumin on IL-10, COX-2, and leukocyte infiltration in a rat model of adenomyosis.
Methods: This experimental study used Rattus norvegicus Wistar strain rats induced with adenomyosis through fluoxetine administration at 8 mg/kg/day for 90 days. The rats were divided into three groups: control, nanocurcumin 50 mg/kg/day, and nanocurcumin 100 mg/kg/day for 14 days. Inflammatory markers were assessed using ELISA and immunohistochemistry.
Results: Rats that received nanocurcumin at a dose of 100 mg/kg/day showed a significant reduction in uterine weight compared to the control group and exhibited anti-inflammatory effects, as indicated by an increase in IL-10 expression in uterine tissue. Additionally, COX-2 expression in the nanocurcumin treatment groups significantly decreased, with the best results observed at a dose of 100 mg/kg/day. Lighter leukocyte infiltration was found in the 100 mg/kg/day nanocurcumin group, demonstrating that nanocurcumin effectively reduces inflammation in the myometrium and endometrium.
Conclusion: Nanocurcumin administration in adenomyosis model rats increases IL-10 expression, decreases COX-2 expression, and reduces leukocyte infiltration in uterine tissue, demonstrating significant anti-inflammatory effects. These findings support the potential of nanocurcumin as an alternative therapy for inflammation in adenomyosis.
Keywords: adenomyosis, COX-2, IL-10, inflammation, nanocurcumin

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2310246497

Penerbit

Pekanbaru : Universitas Riau PASCA Magister Ilmu Biomedis., 2025

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2310246497

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Magister Ilmu Biomedis

Info Detail Spesifik

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Pernyataan Tanggungjawab

Mauli

Versi lain/terkait

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