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Isolasi Senyawa Flavonoid Dari Ekstrak Etil Asetat Daun Rizhophora Apiculata Sebagai Antibakteri Aeromonas Salmonicida Dan Edwardsiella Tarda

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Mangroves are tropical plants that are found in coastal areas and play an important role in preventing abrasion in coastal areas. Mangroves contain various of secondary metabolites which have biological effects in daily life, one of which is antibacterial. Aquaculture often experiences problems in terms of pathogenic bacteria, where bacteria are a major problem causing crop failure. Antibacterial drugs sold on the market have negative effects that can pollute the environment, so an antibacterial drug that is natural and does not damage body waters is needed. The purpose of this study was to determine the potential of pure crystalline activity from the ethyl acetate fraction of mangrove leaves Rhizophora apiculata as antibacterial. Isolation was carried out by maceration using ethanol and fractionation solvents using n-hexane and ethyl acetate. Fractionation results were obtained by crude extract weight of 43.15 grams (1.07% b/b). Then the extract was separated by liquid vacuum chromatography and purified by chromatographic column and recrystallized to obtain 274 mg pure crystals. The characterization was then carried out using UV-VIS, FTIR and 1H-NMR spectroscopy. Spectroscopic results show that the isolated component is a routine (C27H30O16). Based on the antibacterial test of the crude extract of ethyl acetate leaves of Rhizophora apiculata showed antibacterial activity against the bacteria Aeromonas salmonicida with a zone diameter of 9.57 ± 0.60 mm, while positive controls (amoxsan®) had a diameter of inhibition zone of 14.10 ± 0.59 mm. Whereas for routine compounds from ethyl acetate extract of Rhizophora apiculata leaves did not show any antibacterial activity against the bacteria Aeromonas salmonicida and Edwardsiella tarda.
Keywords : antibacterial, extract, fractionation.

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状況

Detail Information

シリースタイトル

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請求記号

03 02. 119 (0030)

公開者

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2019

校合

xi, 29 hlm.: ill.: 29 cm

言語

Indonesia

ISBN/ISSN

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分類

03 02. 119 (0030)

Content Type

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Media Type

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Carrier Type

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刊行

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キーワード

KIMIA

形態

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Statement of Responsibility

JAKA

Other version/related

添付ファイル

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