CD Skripsi

Sintesis Dan Uji Toksisitas Senyawa 5-(4-Bromofenil)-3-(Naftalen-2-Il)-1-Fenil-1h-Pirazol

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Pyrazole is a five rings of heterocyclic compounds with three carbon atoms and two nitrogen atoms in a position that adjacent each other and it has two endocyclic double bonds. Pyrazole has a pharmacological effect on humans and this compound as an important compound in the development of new drugs, one of which is an anticancer drug. Hence, in this study, the synthesis of pyrazole 5-(4-bromofenil)-3-(naftalen-2-il)-1-fenil-1H-pirazol (PZL-4Br) via oxidative aromatization reaction from pyrazoline 5-(4-bromofenil)-3-(naftalen-2-il)-1-fenil-4,5-dihidro-1H-pirazol (PF-4Br-AN2) with glacial acetic acid. Synthesis of the PZL-4Br compound was used the reflux at 80⁰C. The purity of the compound was determined by using TLC, melting point and HPLC analysis. The structure of the synthesized compound was confirmed by UV, FTIR, NMR and HR-MS spectroscopic analysis. The toxicity of PZL-4Br compound was evaluated by Brine Shrimp Lethality Test (BSLT) method with shrimp larvae (Artemia salina Leach). PZL-4Br compound successfully synthesized with 43,96% yield, LC50 = 3435,5 μg/mL which indicates that the compound PZL-4Br is non-toxic.
Keywords: Pyrazole, reflux, toxicity.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 120 (0042)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2020

Deskripsi Fisik

xiv, 34 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 120 (0042)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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