CD Skripsi

Sintesis Dan Studi Molecular Docking Senyawa Pirazolin Dan Pirazol Turunan 4-Kloroasetofenon Dan 3,4-Dimetoksibenzaldehid Sebagai Inhibitor Enzim Tirosinase

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Hyperpigmentation is a disorder of skin pigment that commonly occurs due to an
increase in the process of melanogenesis, which causes changes in skin colour to
appear dark. Pyrazoline and pyrazole are azole compounds with a five-ring
heterocyclic nitrogen atom. Pyrazoline and pyrazole derivatives of 4-
chloroacetophenone and 3,4-dimethoxybenzaldehyde were successfully
shynthesized through the shynthesis of one-pot cyclization of pyrazoline followed
by an oxidative aromatization reaction. The identification was performed by
spectroscopic UV-Vis, FTIR, NMR and HRMS. The target compound was tested
for its bioactivity as a tyrosinase inhibitor through molecular docking of the
tyrosinase crystal structure (PDB ID: 2Y9X) with natural ligands tropolone and
kojic acid as positive controls. The result of docking between the target compounds
pyrazoline and pyrazole and the receptor showed a free binding energy of -10,1885
kkal/mol and -10,4165 kkal/mol, while the free bond energy for kojic acid was-
9,5157 kkal/mol. This can be seen from the interaction of the target compound with
amino acids, which is almost the same as kojic acid. Therefore, it can be concluded
that pyrazoline and pyrazole have potential as tyrosinase enzyme inhibitors.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 121 (0040)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2021

Deskripsi Fisik

xi, 48 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 121 (0040)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

-

Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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