ABSTRACT Pyrazoline is a five-loop compound with two heteroatoms that have various biological activities such as anti-inflammatory, antimicrobial, antidiabetic, antimalarial, anticancer, and antioxidant. This study aims to synthesize pyrazoline compounds by adding variations and increasing their biocativity. Pyrazoline analogue (E)-5-benzyl-7-(4-chlorobenzyliden)-3-(4-chlorophenyl)-2-phenyl-3,…