ABSTRACT Pangasianodon hypophthalmus is a fish with high market demand, but it is very susceptible to attack by the Edwardsiella tarda. One of the natural ingredients that can be used to prevent E.tarda attacks is Muntingia calabura. The research was carried out from 22 December 2019 to 5 February 2020 at the Laboratory of Parasites and Fish Diseases, Faculty of Fisheries and Marine, Riau …