The Siak River in the Pekanbaru City area experienced heavy metal waste pollution in 2016 containing heavy metal Pb ranging from 0.06 - 0.09 mg/L. Pb high levels in the water will affect the structure of fish organs, especially the liver. The study aims to determine changes in the macroscopic and microscopic structure of the liver organ of baung fish (Mystus nemurus CV), as well as Pb levels i…