Leaf mangrove Rhizophora sp. have antimicrobial like tanin, alkaloid, flavonoid, and saponin. The disease Motile Aeromonas Septicaemia by Aeromonas hydrophila caused 100 % mortility in three days. The purpose of the study was to determine the ability of Rhizophora sp. to cure the disease which is caused by MAS (Motile Aeromonas Septicaemia) and showed from the profile of Pangasius hypophthalmus…