CD Skripsi

Ekspresi Monocyte Chemoattractant Protein-1 (Mcp-1) Pada Aorta Tikus Wistar Aterosklerosis Pasca Pemberian Ekstrak Buah Mangrove (Sonneratia Alba)

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ABSTRACT
EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) ATHEROSCLEROTIC RATS AORTA AFTER ADMINISTRATION OF EXTRACT OF MANGROVE FRUIT (Sonneratia alba)
By :
Fitri Tio Arta
Sonneratia alba is a plant that is high in antioxidants such as alkaloids, phenolics, flavonoids, tannins, steroids, terpenoids and saponins. Antioxidants has been proven can prevent foam cell formation, in which MCP-1 plays role in the foam cell formation by recruiting monocytes that take in oxidized-LDL. This study aimed to analyze the effect of mangrove Sonneratia alba fruit extract on expression of MCP-1 in early stages of atherosclerosis in rats fed a high-fat diet. Sixteen paraffin blocks of Rattus norvegicus rats’s abdominal aorta were used in this study which consisted of 3 groups: standard diet (KS), high-fat diet (KP), and high-fat diet and Sonneratia alba fruit extract (KT). Sonneratia alba fruit extract effect on expression of MCP-1 in abdominal aorta was assessed by immunohistochemistry examination. Expression of MCP-1 area was counted in 5 fields of microscopic view and evaluated using the Photoshop Image Analysis program. The results showed that the average percentage of MCP-1 expression in the KS, KP and KT groups was 6,32 ± 1,27%, 24,59 ± 9,68% and 17,45 ± 6,93%. Analysis using One Way Anova showed differences in the area of expression in the three groups, but not significant (p>0.05). Sonneratia alba mangrove extract was not able to significantly suppress MCP-1 expression in the early stages of atherosclerosis. Keywords: Atherosclerosis, Monocyte Chemoattractant Protein-1 (MCP-1) expression, Sonneratia alba, aorta

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1908112652

Penerbit

Pekanbaru : Universitas Riau - Kedokteran - Pendidikan Dokter., 2022

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1908112652

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN DOKTER

Info Detail Spesifik

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Pernyataan Tanggungjawab

Deti

Versi lain/terkait

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