CD Skripsi

Toksisitas Ekstrak Etanol Daun Pelawan (Tristaniopsis Obovata Benn.) Terhadap Organ Hati Tikus Putih (Rattus Novergicus L.)

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Pelawan plant (Tristaniopsis obovata Benn.) used by the community as traditional medicine to treat various diseases. Giving the extract determines whether the animal is safe or not from the Lethal Dose (LD50) test. The research aims to determine the LD50 value, clinical symptoms due to administration of ethanol extract of Pelawan leaves, and the influence of toxic effects on the liver structure of white rats (Rattus novergicus L.). The research used a Completely Randomized Design (CRD), 16 rats were divided into 4 treatments, namely P0 (control), P1 (dose 300 mg/kg BW), P2 (dose 2000 mg/kg BW), and P3 (dose 5000 mg/kg BW). The results of research on clinical symptoms show a decrease in physical activity, decreased respiratory rate, convulsions, decreased appetite and drinking. The toxicity test of the ethanol extract of Pelawan leaves by determining the LD50 in white mice showed a value of 1.750 mg/kg BW which was included in the mild toxic category. The structure of the rat liver due to administration of the extract experienced microscopic structural changes such as changes in hepatocyte cell structure, parenchymal degeneration occurred 18.44% (P3), 21.95% (P0), 25.26% (P1), and 31.77% (P2 ), hydropic degeneration 4.67% (P0), 7.02% (P1), 8.06% (P3) and 12.14% (P2), fatty degeneration 3.95% (P0), 4.06 ( P3), 9.76% (P2), 29.31% (P1) and necrosis 3.36% (P0), 5.16% (P1), 33.17% (P2), and 56.52% ( P3). Administration of ethanol extract can cause mild toxicity and changes in hepatocyte cell structure, thought to be due to secondary metabolite compounds present in Pelawan leaf extract. In high doses it will be toxic to liver tissue.

Keywords: Tristaniopsis obovata Benn., Toxicity, LD50, Extract

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2003126801

Penerbit

Pekanbaru : Universitas Riau FMIPA Biologi., 2024

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2003126801

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

BIOLOGI

Info Detail Spesifik

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Pernyataan Tanggungjawab

mardiah

Versi lain/terkait

Lampiran Berkas

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