CD Skripsi

Uji Toksisits Ekstrak Etanol Daun Mangifera Sumatrana Terhadap Keragaan Morfologi Dan Histologi Hati Tikus Putih (Rattus Norvegicus L.) Galur Sprague-Dawley Yang Diberi Aloksan

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Mangifera sumatrana is a type of mango endemic to Sumatra which has the potential to be a natural anti-diabetic agent. This study aims to evaluate the toxicity of ethanol extract of M. sumatrana leaves on the morphological and histological performance of the liver given alloxan. Ethanol extract of M. sumatrana leaves was administered orally at doses of 500, 1000, 2000, and 4000 mg/kg BW to male Sprague-Dawley rats, a model of alloxan-induced diabetes. Observations were made on mortality, body weight, signs of toxicity, and liver histology for 14 days. The results showed that there were no mouse deaths in all treatment groups. Significant weight loss occurred at doses of 1000-4000 mg/kg BW. Morphological changes in the form of dull fur and nasal inflammation were observed at high doses. Liver histology showed a hepatoprotective effect at a dose of 500-1000 mg/kg BW, but signs of hepatic toxicity were observed at a dose of 2000-4000 mg/kg BW. This research indicates that the ethanol extract of M. sumatrana leaves has low toxicity at therapeutic doses, but has the potential to be hepatotoxic at high doses. Further studies are needed to confirm the safety and efficacy of this extract as an antidiabetic agent.
Key findings: Mangifera sumatrana, diabetes, toxicity, liver histology, hepatoprotective

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1703110266

Penerbit

Pekanbaru : Universitas Riau FMIFA Biologi., 2024

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1703110266

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

BIOLOGI

Info Detail Spesifik

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Pernyataan Tanggungjawab

ERA

Versi lain/terkait

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