Image of Hubungan Kadar N-Asetiltransferase 2 (NAT2) dan Xantin Oksidase (XO) Terhadap Peningkatan Enzim Hati Pada Pasien Tuberkulosis yang Menggunakan Obat Anti Tuberkulosis Kombinasi Dosis Tetap (OAT KDT) Di Provinsi Riau
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Hubungan Kadar N-Asetiltransferase 2 (NAT2) dan Xantin Oksidase (XO) Terhadap Peningkatan Enzim Hati Pada Pasien Tuberkulosis yang Menggunakan Obat Anti Tuberkulosis Kombinasi Dosis Tetap (OAT KDT) Di Provinsi Riau

Introduction: Hepatotoxicity associated with ATD is difficult to predict because most TB patients use a combination of drugs during therapy. Many factors influence the incidence of drug-induced hepatitis, one of which is the drug metabolism process. Drug metabolism in the liver is greatly influenced by the content and activity levels of drug-metabolizing enzymes such as N-Acetyltransferase 2 (NAT2) metabolizing isoniazid and Xanthine Oxidase (XO) metabolizing pyrazinamide. The ability to quantitatively determine individual NAT2 and XO enzyme levels will be essential to assess liver damage caused by ATD.
Methods: This study is an observational analytical study with a cohort design conducted at Arifin Achmad Hospital from December 2023 to March 2024 in the early phase of treatment with ATD patients. A total of 35 TB patients who met the inclusion criteria were examined for NAT2 and XO enzyme levels and using ELISA and liver function biomarker examinations at the beginning of treatment and at the end of the second month of treatment or when liver function disorders occurred. Then it was assessed whether there was a relationship between NAT2 and XO enzyme levels and an increase in liver function biomarker values.
Results: Based on the results of this study, it was found that increasing NAT2 levels did not have a significant relationship with increasing liver enzymes with a p value > 0.05. The results of further studies found that between the XO level variable and increasing liver enzymes there was a significant relationship with a p value < 0.05. The relationship value based on the Person correlation coefficient is known to have a strong relationship with a correlation coefficient value approaching one, which is 0.5.
Conclusion: Increased NAT2 levels have no relationship with increased liver enzymes, furthermore, increased XO levels have a significant relationship with increased liver enzymes in tuberculosis patients using ATD in Riau Province.

Keywords: Hepatotoxicity, Isoniazid, Pyrazinamide, NAT2, XO

Ketersediaan
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Perpustakaan Universitas Riau 2010241689
2010241689
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Judul Seri
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No. Panggil
2010241689
Penerbit
Pekanbaru : Universitas Riau – Pascasarjana – Pulmonologi dan Ilmu Kedokteran Respirasi.,
Deskripsi Fisik
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Bahasa
Indonesia
ISBN/ISSN
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Klasifikasi
2010241689
Tipe Isi
-
Tipe Media
-
Tipe Pembawa
-
Edisi
-
Subjek
Pulmonologi dan Ilmu Kedokteran Respirasi
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