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Efek Pemberian Akrilamida Terhadap Kadar Kolesterol Darah Dan Asam Urat Tikus Putih Galur Wistar Rattus Norvegicus (Berkenhout, 1769)
Acrylamide is a toxic compound that is formed in foods heated above 120°C and can trigger oxidative stress that disrupts the body's metabolism. This study aims to determine the effect of acrylamide administration on cholesterol and uric acid levels in Wistar white rats. The study used 16 male rats which were divided into four treatments: P0 (control), P1 (2.5 µg/kg BW), P2 (5 µg/kg BW), and P3 (10 µg/kg BW), each with four replicates. Acrylamide was administered orally for 14 days, and cholesterol and uric acid levels were measured on days 0, 7, and 14 using the Nesco Multicheck device. Data analysis using ANOVA and Duncan's test showed that cholesterol levels in treatments P1 and P3 were significantly different from the control, while P2 was not significantly different. In uric acid levels, the control was significantly different from all treatments, but there were no significant differences between treatments P1, P2, and P3. Cholesterol and uric acid levels tended to increase during treatment although still within the physiological range.
Key words: Acrylamide, cholesterol, oxidative stress, Rattus norvegicus, uric acid
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